An evidence pyramid visually depicts the evidential strength of different research designs. The image below is one of several available renderings of an evidence pyramid. Studies with the highest internal validity, characterized by a high degree of quantitative analysis, review, analysis, and stringent scientific methodology, are at the top of the pyramid. Observational research and expert opinion reside at the bottom of the pyramid.
Systematic Reviews Made Simple!
Watch this video for a great overview of Systematic Reviews: What they are, why we need them, and a real-life example of how practical they are.
Meta-Analysis Made More Fun!
Now check out this video for a great explanation of Meta-analysis: What they are/How they work, controversies, and a real-life example of how to critically appraise them.
A summary of the clinical literature. A systematic review is a critical assessment and evaluation of all research studies that address a particular clinical issue. The researchers use an organized method of locating, assembling, and evaluating a body of literature on a particular topic using a set of specific criteria. A systematic review typically includes a description of the findings of the collection of research studies. [AHRQ Glossary of Terms]
A work consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature. [PubMed]
Randomized Controlled Trial
A controlled clinical trial that randomly (by chance) assigns participants to two or more groups. There are various methods to randomize study participants to their groups. [AHRQ Glossary of Terms]
Controlled Clinical Trial
A type of clinical trial comparing the effectiveness of one medication or treatment with the effectiveness of another medication or treatment. In many controlled trials, the other treatment is a placebo (inactive substance) and is considered the "control." [AHRQ Glossary of Terms]
A clinical research study in which people who presently have a certain condition or receive a particular treatment are followed over time and compared with another group of people who are not affected by the condition. [AHRQ Glossary of Terms]
Case Control Study
The observational epidemiologic study of persons with the disease (or other outcome variable) of interest and a suitable control (comparison, reference) group of persons without the disease. The relationship of an attribute to the disease is examined by comparing the diseased and nondiseased with regard to how frequently the attribute is present or, if quantitative, the levels of the attribute, in each of the groups. [OCEBM Table of Evidence Glossary]
A group or series of case reports involving patients who were given similar treatment. Reports of case series usually contain detailed information about the individual patients. This includes demographic information (for example, age, gender, ethnic origin) and information on diagnosis, treatment, response to treatment, and follow-up after treatment. [OCEBM Table of Evidence Glossary]
An investigation of a single subject or a single unit, which could be a small number of individuals who seem to be representative of a larger group or very different from it. [Dictionary of Nursing Theory and Research, Fourth Edition]
Work consisting of a statement of the opinions, beliefs, and policy of the editor or publisher of a journal, usually on current matters of medical or scientific significance to the medical community or society at large. The editorials published by editors of journals representing the official organ of a society or organization are generally substantive. [PubMed]
A belief or conclusion held with confidence but not substantiated by positive knowledge or proof. [The Free Dictionary]
A laboratory experiment using animals to study the development and progression of diseases. Animal studies also test how safe and effective new treatments are before they are tested in people. [NCI Dictionary of Cancer Terms]
In Vitro Research
In the laboratory (outside the body). The opposite of in vivo (in the body). [NCI Dictionary of Cancer Terms]
AHRQ: Agency for Healthcare Research and Quality; OCEBM: Oxford Centre for Evidence Based Medicine
From: John Moritz Library's EBP LibGuide.
Therapy: Which treatment does more harm than good?
RCT → Cohort Study → Case Control → Case Series
Diagnosis: Which diagnostic test should I use?
Prospective, blind comparison to a gold standard, ie. A controlled trial that looks at patients with varying degrees of an illness and administers both diagnostic tests -- the test under investigation and the "gold standard" test -- to all of the patients in the study group.
Prognosis: What is the patient's likely clinical course over time?
Cohort Study → Case Control → Case Series
Etiology/Harm: What are the causes of this disease or condition?
RCT → Cohort Study→ Case Control → Case Series
Prevention: How do we reduce the chance of disease by identifying and modifying risk factors?
RCT → Cohort Study → Case Control → Case Series
Cost: Is one intervention more cost-effective than another?
Quality of Life: What will be the patient's quality of life following an intervention?